|
KMID : 0357119930150020227
|
|
Korean Journal of Immunology
1993 Volume.15 No. 2 p.227 ~ p.233
|
|
|
Effects of Ascorbate on the Differentiation of B Lymphocytes in Sarcoma 180-implanted Mice
|
|
Kang Young-Jun
Roh Jeong-Hye
Kang Sa-Ouk
Jeong Ga-Jin
|
|
|
Abstract
|
|
|
|
Ascorbate is one of the important radical scavengers. Its roles in biological system including anti-cancer effects have been broadly studied. Ascorbate recovered the function of B lymphocytes which was suppressed by Sarcoma 180-derived immunosuppressive factor(s). Production of anti-SRBC antidody was increased by the adminisration of ascorbate in the Sarcoma 180 culture supernatant-treated mice. Ascorbate enhanced the suppressed immune function of tumor-bearing hosts. Treatment of 1 mg of ascorbate increased the function of B lymphocytes, however, 10ug of ascorbate treatment decreased. In vitro treatment of ascorbate increased the immunoglobulin production ac-cording to the increasement of ascorbate concentration. These results also imply that ascorbate may be a immunoreeulatory molecule.
|
|
|
KEYWORD
|
|
|
Ascorbate, Sarcoma 180, B lymphocytes Differentiation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|